In case of significant obstruction of the esophageal lumen by esophageal web and persistent dysphagia despite iron supplementation, rupture and dilation of the web are necessary. Plummervinson syndrome is known to be associated with an increased risk of upper alimentary tract cancers, and the incidence rate of upper esophageal cancer in this syndrome is 315% so a close monitoring of these patients is advisable. Indeed, impaired esophageal motility has been described in plummervinson syndrome and it was corrected by iron treatment 38,39. Fahmi yousef khan, a haleem elhiday and nader a morad. People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe esophagus. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Disease definition plummer vinson or siferopenica syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal webs. Plummervinson syndrome pvs is a triad of microcytic hypochromic anaemia iron deficiency, atrophic glossitis, and oesophageal webs or strictures. In this connection, the socalled sideropenic dysphagia is also reported in cases of pronounced chronic iron deficiency, in which a membrane forms in the. Plummer vinson syndrome pvs is a triad of microcytic hypochromic anemia, atrophic glossitis, and esophageal webs or strictures. Declaration of conflicting interests the authors declared no potential conflicts ofinterest withrespect to the research, authorship, andor publication of this article. In 1912, plummer reported a series of twenty one patients with longstanding iron deficiency anaemia, dysphagia and spasm of the upper oesophagus without anatomic. Dysphagia is defined as an inefficiency in transferring food, liquid, or saliva from the oral cavity to the stomach tjaden, 2008 and is a common symptom among pd patients, tending to develop after the appearance of dysarthria, which. Pvs is discussed in terms of its history, etiology, epidemiology, clinical presentation, diagnosis, treatment and the significant.
Plummer vinson syndrome classically presents as a triad of irondeficiency anaemia, postcricoid dysphagia and upper esophageal webs. Pvs is a rare disease whose evolution is usually favorable under treatment. Plummervinson syndrome atmatzidis 2003 diseases of. Plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, iron deficiency anemia and esophageal webs. Iron deficiency is the commonest systematic complication of crohns disease with only one described case of a crohns disease patient combined with pvs in the literature. The term sideropenic dysphagia has also been used, because the syndrome can occur with iron deficiency sideropenia. The plummer vinson syndrome, also called the patersonbrownkelly syndrome, consists of a triad of dysphagia, iron deficiency anemia, and esophageal webs. Esophagus cancer causes, risk factors, and prevention. The plummer vinson syndrome with mucosal shrinkage of the tongue, oesophagus and pharynx, combined with tongue burning and swallowing disorders, occurs in iron deficiency. Plummervinson syndrome chiachun liu, yaohshiang lin, 2019. The association of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia is known as plummer vinson syndrome pvs in the united states and patersonbrown kelly syndrome in the united kingdom.
To report the epidemiological, clinical, paraclinical and histological characteristics of patients with plummer vinson syndrome associated with esophageal cancer. While this syndrome is known as plummer vinson syndrome in the united states, it is known as patersonbrown kelly syndrome in the united kingdom. The mainstay of treatment for pvs is aimed at correcting iron deficiency anemia. The term sideropenic dysphagia has also been used, since the syndrome can occur with iron deficiency sideropenia, but it is not as. Revisiting plummer vinson syndrome gude d, bansal dp1, malu a internal medicine, 1pulmonology and critical care, medwin hospital, nampally, hyderabad, andhra pradesh, india abstract plummer vinson syndrome is a rare association of postcricoid dysphagia. Plummervinson syndrome can be treated effectively with iron. Plummervinson syndrome with simultaneous midesophageal growth mukesh nasa1, gaurav patil 2, zubin sharma, rajesh puri3 abstract patterson brown kelly or plummer vinson syndrome is characterized by dysphagia, iron deficiency anemia and postcricoidal esophageal web. Investigation revealed a number of distinct esophageal disorders including plummer vinson syndrome, gastroesophageal reflux disease with esophagitis, distal esophageal stricture, esophageal intramural pseudodiverticulosis, and. One of the main characteristics of pvs is the significant dysphagia swallowing disorder that occurs due to the presence of esophageal webs. Plummer vinson syndrome pvs is a rare pathology combining dysphagia, an iron deficiency anemia and a cervical esophageal web.
Jie deng orthobullets team orthobullets team 0 % topic. Plummervinson syndrome pvs also named as pattersonbrownkelly syndrome is a combined presentation of three things dysphagia, iron deficiency anemia, and esophageal webs, seen more often in. Pdf on feb 7, 2019, moussa diallo and others published a plummer vinson syndrome related to. Plummervinson syndrome is a rare condition associated with dysphagia, iron deficiency, and esophageal webs.
This name comes from two americans named henry stanley plummer and porter paisley vinson. Plummer vinson syndrome is a rare condition associated with dysphagia, iron deficiency, and esophageal webs. Rapidly progressive plummer michael skolka and vinson. After the treatment, the patients dysphagia was relieved.
Plummervinson syndrome with esophageal web formation in. Plummer vinson syndrome pvs is a rare pathology combining. Plummervinson syndrome and esophageal cancer in an. Plummervinson syndrome has been identified as a risk factor for developing squamous cell carcinoma of the upper gastrointestinal tract. Three to 15 per cent of the patients with plummervinson syndrome, mostly women between 15 and 50 years of age, have been reported to develop esophageal or pharyngeal cancer 15,16. Identification and followup is relevant due to increased risk of squamous cell carcinomas of the esophagus and pharynx. Plummer vinson syndrome people with this rare syndrome also called patersonkelly syndrome have webs in the upper part of the esophagus, typically along with anemia low red blood cell counts due to low iron levels, tongue irritation glossitis, brittle fingernails, and sometimes a. Plummervinson syndrome is a condition that can occur in people with longterm chronic iron deficiency anemia. Plummer vinson syndrome symptoms, diagnosis, treatment. Efficiency and safety of endoscopic dilation of the plummervinson.
Patients must be screened regularly for any development of upper gastrointestinal malignancy. Symptoms resulting from anemia predominates the clinical picture, apart from the additional features such as glossitis, angular cheilitis, and dysphagia. Both patients presented with dysphagia, anemia, sideropenia, glossitis and cheilitis. Kelly syndrome pvs is a rare entity comprising upper esophageal webs and iron deficiency anemia. Elemental iron in the range of 150200 mg is required for correction of iron deficiency anemia which in most cases corrects. If it happens again, he discards the hotdog but sometimes he can. Plummer vinson syndrome pvs is characterized by a triad of symptoms comprising microcytic hypochromic anemia, esophageal webs, and dysphagia. We report a case of a 39yearold female patient who had a classic presentation of pvs. It is one of the risk factors of the esophageal cancer. Plummer was a prominent internist and endocrinologist born in 1874 and was one of the founding members of the mayo clinic. Plummer vinson syndrome treatment the first step in the management of pvs is to make clear the cause for the iron deficiency so as to exclude any active bleeding, malignancy or celiac disease. Plummer vinson syndrome is characterized by dysphagia, iron deficiency, anemia and the presence of esophageal web or webs. Plummervinson syndrome is a rare entity, characterized by dysphagia, esophageal web formation. Plummer vinson syndrome synonyms, plummer vinson syndrome pronunciation, plummer vinson syndrome translation, english dictionary definition of plummer vinson syndrome.
Plummer vinson paterson, brownkelly syndrome refers to the association of irondeficiency anaemia with dysphagia secondary to a postcricoid web. Plummervinson syndrome in a crohns disease patient. It is one of the syndromes associated with iron deficiency anemia. Treatment for pvs includes iron replacement, and in some cases requires mechanical dilation. Plummervinson syndrome can be treated effectively with iron supplementation and mechanical dilation.
The only treatment they did was to place a gastrostomy tube to feed her. Three to 15 per cent of the patients with plummervinson syndrome, mostly women between 15 and 50 years of age, have been reported to. Still called sideropenic dysphagia, the plummervinson. It typically affects middle aged females who may have other features of chronic iron deficiency, namely papillary atrophy of the tongue, spoon shaped brittle nails, angular stomatitis and pica. Treatment of the iron deficiency frequently relieves dysphagia though some patients may need endoscopic web dilatation. We report a case of pvs in a 62yearold patient admitted to the department of gastroenterology an\ d internal medicine for high dysphagia. A 58yearold woman with iron deficiency anemia presents to her primary care physician complaining of difficulty swallowing. Summary plummer vinson syndrome is characterized by dysphagia, iron deficiency, anemia and the presence of esophageal web or webs. Even though the syndrome is very rare nowadays, its recognition is important because it identifies a group of patients at increased risk of squamous cell carcinoma of the pharynx and the esophagus. Whats where the does name plummer vinson syndrome come from. Revisiting plummer vinson syndrome annals of medical and. It has been known since the beginning of the 20th century.
Declaration of conflicting interests the authors declared no potential conflicts of interest with respect to the research, authorship, andor publication of this article. Management and treatment plummer vinson syndrome can be treated effectively with iron supplementation and mechanical dilation. Pdf a plummer vinson syndrome related to pregnancy and. Plummervinson syndrome is defined by the classic triad of dysphagia, irondeficiency anemia and esophageal webs. Plummer vinson syndrome pvs is named after henry stanley plummer and porter paisley vinson, who were physicians on the staff of the mayo clinic. Only seven cases of plummer vinson syndrome in children and adolescents between the. Plummer vinson syndrome pvs, a rare condition complicating iron deficiency anaemia, manifests as a classic triad of dysphagia, anaemia and oesophageal web. Plummer vinson syndrome also known as paterson brownkelly syndrome is a syndrome associated with the triad of symptoms comprising microcytic hypochromic anemia, oesophageal strictures, and dysphagia. A description of this syndrome was published by henry plummer in chicago in 1911 and also by porter vinson in philadelphia in 1919. Plummervinson syndrome definition of plummervinson.
We report a 39yearold native american female with an almost 20year history of dysphagia that had increased in the 6 months prior to the initial evaluation. Revisiting plummer vinson syndrome a report of three cases. A group of symptoms that collectively indicate or characterize a disease, disorder, or other condition considered abnormal. Various reports have shown that treatment of iron deficiency anemia.
The association of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia is known as plummervinson syndrome pvs in the united states and patersonbrown kelly syndrome in the united kingdom. Rapidly progressive plummer vinson syndrome initial studies included a cbc which showed a microcytic anemia with hgb 6. An 11 year old boy complains that occasionally a bite of hotdog gives mild pressing pain in his chest and that it takes a while before he can take another bite. Definition plummervinson syndrome pvs is a classical triad of postcricoid dysphagia, upper esophageal webs, and iron deficiency anemia. Plummervinson syndrome pvs is a rare condition characterized by. The cuplike or spoonlike depression of the nail is centrally located, and may be of such a degree that a. Pvs can easily be treated and effectively with iron supplements and mechanical dilation. Plummervinson or patersonkelly syndrome presents as a classical triad of dysphagia, irondeficiency anemia and esophageal webs. Plummervinson syndrome an overview sciencedirect topics. Although most cases have a benign and indolent course, the risk of malignancy warrants longterm surveillance. A holistic approach to diagnosing and treating dysphagia.
Data regarding this condition is limited to mostly case reports and a few small cohort studies. In cases in which spoon nails seem to be associated with some or all of the various components of the plummer vinson syndrome, the most constant finding is that of an associated anemia. Pvs is commonly found in women of middle age especially in the fourth and fifth decade of life and is rarely reported in males. Plummer vinson syndrome \pvs\ is a rare condition characterized by classical triad. Abstract plummervinson syndrome pvs is a rare disorder characterized by iron deficiency anemia, post cricoid dysphagia and. Two cases of this syndrome are reported in middleaged women, which were treated over the last eight years. Plummervinson syndrome with simultaneous midesophageal. Plummervinson syndrome a rare presentation in a child. Plummervinson syndrome gastrointestinal medbullets. Plummervinson syndrome, if left untreated, carries an increased risk of developing squamous cell carcinoma of the upper alimentary tract. Department of medicine, university of california, san diego, california. Endoscopy of plummervinson syndrome associated with longstanding and.
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